Additive Wake-Promoting Actions of Medial Basal Forebrain Noradrenergic 1- and -Receptor Stimulation
نویسنده
چکیده
The locus coeruleus–noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part through the actions of noradrenergic -receptors in the medial septal (MS) and medial preoptic (MPOA) areas. MPOA 1-receptors exert similar wake-promoting actions. The current study examines the influence of 1-receptors located within MS on sleep–wake state. In addition, the extent to which 1and -receptors located within MS and MPOA interact in the modulation of behavioral state was investigated by examining the effects of individual or combined infusion of 1and -agonists into these regions. Results show that 1-receptors located within MS exert wake-promoting actions. Within both MS and MPOA, additive wake-promoting actions were observed with 1and -receptor stimulation, the sum of which contributes to the overall arousal state of the animal.
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